Ledderhose Disease: Symptoms, Causes & Treatment (2024)

What is Ledderhose disease?

Ledderhose disease (plantar fibromatosis) is a rare disease. It affects the plantar fascia, which is the thick layer of tissue (ligament) that protects and supports the bottom of your foot. If you have Ledderhose disease, small, hard nodules develop slowly on the bottom of your feet. These nodules are noncancerous (benign) thickening of this ligament. They look like bumps, knots or growths on the surface of your skin. The bumps may grow to be 1 to 2 centimeters in size.

What are the stages of Ledderhose disease?

There are three stages to Ledderhose disease:

• Stage I: There's an increase in the number of cells in the area.
• Stage II: A growth or knot forms on your skin.
• Stage III: The tissue squeezes together (contracts). Your toes may contract too.

Who does Ledderhose disease affect?

Ledderhose disease affects people of any age. However, it’s more common in men who are middle-aged or older.

Ledderhose disease often affects those who have:

• Dupuytren’s disease.
• Peyronie’s disease.
• Thickening over the tops of your finger joints (knuckle pads).
• Frozen shoulder.
• Epilepsy.
• Alcohol use disorder.

How common is Ledderhose disease?

Ledderhose disease affects less than 200,000 people in the United States every year. However, it becomes more common in middle-aged or older people, with up to 25% developing the disease.

In 25% of cases, Ledderhose disease affects both feet.

How does Ledderhose disease affect my body?

Ledderhose disease may cause discomfort. Your feet may become swollen, and the growths on your feet may be painful. These issues can affect your ability to walk.

In rare cases, your toes may curl down toward the bottom of your feet. It may be difficult or even impossible to straighten your toes. It tightens the ligament on the bottom of your foot (plantar fascia) and can predispose you to developing plantar fasciitis.